Lisa McTeague, PhD

Triangulating Treatment Personalization: Psychophysiology, Imaging and Engineering

Lisa M. McTeague, Ph.D., is an Associate Professor in the Department of Psychiatry, Brain Stimulation Division at the Medical University of South Carolina and a licensed clinical psychologist in the PTSD Clinical Team at the Ralph H. Johnson VAHCS. Dr. McTeague’s work in cognitive and affective neuroscience has consistently been transdiagnostic, examining multimodal, neurobehavioral phenotypes (e.g., EEG, MRI, autonomic physiology, self-support, behavior) of emotional and cognitive dysfunction within but also between neuropsychiatric (i.e., PTSD, depression, substance use disorders) and neurodegenerative (e.g., vascular cognitive impairment, mild cognitive impairment, stroke, Parkinson’s Disease) conditions. Her group has consistently observed that across disorders, emotional and cognitive impairment is related to disruptions in the neurocircuits and downstream systems that support intact or adaptive emotion and cognition. As such, they have utilized these findings as a roadmap for non-invasive brain stimulation (rTMS, taVNS, tDCS, tFUS) development as isolated or adjunctive treatments for the most promising behavioral and pharmacological interventions.

Reading List

Caulfield KA, Fleischmann HH, George MS, McTeague LM. A transdiagnostic review of safety, efficacy, and parameter space in accelerated transcranial magnetic stimulation. J Psychiatr Res. 2022 Aug;152:384-396. doi: 10.1016/j.jpsychires.2022.06.038. Epub 2022 Jun 28. PMID: 35816982; PMCID: PMC10029148.

George MS, Huffman S, Doose J, Sun X, Dancy M, Faller J, Li X, Yuan H, Goldman RI, Sajda P, Brown TR. EEG synchronized left prefrontal transcranial magnetic stimulation (TMS) for treatment resistant depression is feasible and produces an entrainment dependent clinical response: A randomized controlled double blind clinical trial. Brain Stimul. 2023 Nov-Dec;16(6):1753-1763. doi: 10.1016/j.brs.2023.11.010. Epub 2023 Dec 2. PMID: 38043646; PMCID: PMC10872322.

He H, Sun X, Doose J, Faller J, McIntosh JR, Saber GT, Huffman S, Hong L, Pantazatos SP, Yuan H, McTeague LM, Goldman RI, Brown TR, George MS, Sajda P. TMS-induced modulation of brain networks and its associations to rTMS treatment for depression: a current fMRI-EEG-TMS study. Brain Stimul. 2025 Nov-Dec;18(6):1955-1965. doi: 10.1016/j.brs.2025.10.013. Epub 2025 Oct 16. PMID: 41109521; PMCID: PMC12716231.

McTeague LM, Huemer J, Carreon DM, Jiang Y, Eickhoff SB, Etkin A. Identification of Common Neural Circuit Disruptions in Cognitive Control Across Psychiatric Disorders. Am J Psychiatry. 2017 Jul 1;174(7):676-685. doi: 10.1176/appi.ajp.2017.16040400. Epub 2017 Mar 21. PMID: 28320224; PMCID: PMC5543416.

McTeague LM, Rosenberg BM, Lopez JW, Carreon DM, Huemer J, Jiang Y, Chick CF, Eickhoff SB, Etkin A. Identification of Common Neural Circuit Disruptions in Emotional Processing Across Psychiatric Disorders. Am J Psychiatry. 2020 May 1;177(5):411-421. doi: 10.1176/appi.ajp.2019.18111271. Epub 2020 Jan 22. PMID: 31964160; PMCID: PMC7280468.